反应条件
1: SOCl2 / 0.5 h / Heating
2: 1.) BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, from -78 deg C to RT, 3 h
3: 1.) (i-Pr)2NEt, Bu2BOTf, 2.) NBS / 1.) CH2Cl2, from -78 deg C to 0 deg C, 75 min, 2.) CH2Cl2, -78 deg C, 1.25 h
4: 76 percent / tetramethylguanidinium azide / CH2Cl2 / 3 h / 0 °C
5: 82 percent / aq. H2O2, LiOH / tetrahydrofuran / 0.5 h / 0 °C
6: 81 percent / H2, aq. AcOH / 10percent Pd/C / 23 h / 2068.6 Torr
View Scheme
参考文献
Larsson, Ulf; Carlson, Rolf; Leroy, Jacques
Acta Chemica Scandinavica, 1993 , vol. 47, # 4 p. 380 - 390
