2-(2-乙炔苯氧基)四氢-2H-吡喃合成路线 （共 7 条）
反应条件
potassium hydroxide in methanol; dichloromethane T=20°C; desilylation; 4 h;
参考文献
Crisp, Geoffrey T.; Bubner, Timothy P.
Tetrahedron, 1997 , vol. 53, # 34 p. 11881 - 11898
反应条件
hydrogenchloride in ethyl acetate T=50°C; 48 h;
参考文献
Obrecht, Daniel
Helvetica Chimica Acta, 1989 , vol. 72, p. 447 - 456
反应条件
1: Pd(Ph3P)2Cl2; CuI; Et3N / 6 h / 20 °C 2: KOH / CH2Cl2; methanol / 0.5 h / 20 °C View Scheme
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Moro, Leonardo
Synlett, 1998 , # 7 p. 741 - 745
反应条件
1: p-toluenesulfonic acid / 3 h / 20 °C 2: Pd(Ph3P)2Cl2; CuI; Et3N / 6 h / 20 °C 3: KOH / CH2Cl2; methanol / 0.5 h / 20 °C View Scheme
参考文献
Crisp, Geoffrey T.; Bubner, Timothy P.
Tetrahedron, 1997 , vol. 53, # 34 p. 11881 - 11898
反应条件
1: p-toluenesulfonic acid / 3 h / 20 °C 2: Pd(Ph3P)2Cl2; CuI; Et3N / 6 h / 20 °C 3: KOH / CH2Cl2; methanol / 0.5 h / 20 °C View Scheme
参考文献
Crisp, Geoffrey T.; Bubner, Timothy P.
Tetrahedron, 1997 , vol. 53, # 34 p. 11881 - 11898
反应条件
water; toluene-4-sulfonic acid in acetone Ambient temperature;
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Moro, Leonardo
Synlett, 1998 , # 7 p. 741 - 745
反应条件
1: BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) 0 deg C, 30 min
2: MnO2 / CH2Cl2 / 0.75 h / 0 °C
3: 2.3 g / pyridinium p-toluenesulfonate (PPTS) / ethanol / 50 °C
4: 80 percent / 4N HBr / dioxane; H2O / 3.5 h / 65 °C
View Scheme
参考文献
Obrecht, Daniel
Helvetica Chimica Acta, 1989 , vol. 72, p. 447 - 456
