3,3',5,5'-四溴-2,2'-联噻吩合成路线 （共 18 条）
反应条件
1: 3,3',5,5'-tetrabromo-2,2'-bithiophene-3,3',5,5'-tetrabromo-2,2'-bithiophene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=20°C; 18 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 12, # 15 p. 2474 - 2478
反应条件
1: 3,3',5,5'-tetrabromo-2,2'-bithiophene-3,3',5,5'-tetrabromo-2,2'-bithiophene With n-butyllithium in diethyl ether T=-78 - 20°C; 6 h; 2: trimethylsilyl bromide in diethyl ether
参考文献
WO2008/109701 A1, ;
Page/Page column 26 ;
反应条件
n-butyllithium; chloro-trimethyl-silane in ethanol; hexane
反应条件
1: 88 percent / Zn, glacial AcOH / propan-1-ol; H2O / Heating 2: 1.) Mg, I2, 2.) bis(1,3-diphenylphosphino)propane nickel(II) chloride (NiCl2*dppp) / 1.) ether, RT, 1 h, 2.) ether, RT, overnight View Scheme
参考文献
Khor, Eugene; Ng, Siu Choon; Li, Hwee, Chze; Chai, Selenium
Heterocycles, 1991 , vol. 32, # 9 p. 1805 - 1812
反应条件
1: 88 percent / Zn, glacial AcOH / propan-1-ol; H2O / Heating 2: 1.) Mg, I2, 2.) bis(1,3-diphenylphosphino)propane nickel(II) chloride (NiCl2*dppp) / 1.) ether, RT, 1 h, 2.) ether, RT, overnight View Scheme
参考文献
Khor, Eugene; Ng, Siu Choon; Li, Hwee, Chze; Chai, Selenium
Heterocycles, 1991 , vol. 32, # 9 p. 1805 - 1812
反应条件
1.1: n-butyllithium / diethyl ether / |Inert atmosphere 1.2: |Inert atmosphere 2.1: n-butyllithium / hexane; tetrahydrofuran / -60 - -30 °C / |Inert atmosphere 2.2: -30 - 0 °C / |Inert atmosphere 3.1: trifluoroacetic acid / chloroform / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 18 p. 4642 - 4645
反应条件
1.1: hydrogenchloride; acetic acid; zinc / ethanol; water / Inert atmosphere; Reflux 2.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 3 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Beaujuge, Pierre M.; Tsao, Hoi Nok; Hansen, Michael Ryan; Amb, Chad M.; Risko, Chad; Subbiah, Jegadesan; Choudhury, Kaushik Roy; Mavrinskiy, Alexei; Pisula, Wojciech; Bredas, Jean-Luc; So, Franky; Muellen, Klaus; Reynolds, John R.
Journal of the American Chemical Society, 2012 , vol. 134, # 21 p. 8944 - 8957
反应条件
1.1: n-butyllithium / diethyl ether; hexane / -78 - 0 °C 1.2: 17 h / 20 °C / Reflux 2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C 2.2: -78 °C / Reflux 3.1: N-bromosuccinmide / chloroform; acetic acid / 16 h / 20 °C View Scheme
参考文献
Chen, Chiu-Hsiang; Hsieh, Chao-Hsiang; Dubosc, Martin; Cheng, Yen-Ju; Hsu, Chain-Shu
Macromolecules, 2010 , vol. 43, # 2 p. 697 - 708
