[(3aR,5R,6S,6aR)-5-[(1R)-1,2-二羟基乙基]-2,2-二甲基-3a,5,6,6a-四氢呋喃并[4,5-d][1,3]二氧杂环戊烯-6-基] 丁酸酯合成路线 （共 3 条）
→
125161-47-9[(3aR,5R,6S,6aR)-5-[(1R)-1,2-二羟基乙基]-2,2-二甲基-3a,5,6,6a-四氢呋喃并[4,5-d][1,3]二氧杂环戊烯-6-基] 丁酸酯
反应条件
sulfuric acid in ethanol T=50°C;
参考文献
Goueth, Pierre Y.; Gogalis, Pascalis; Bikanga, Raphael; Gode, Paul; Postel, Denis; et al.
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 2 p. 249 - 272
→
125161-47-9[(3aR,5R,6S,6aR)-5-[(1R)-1,2-二羟基乙基]-2,2-二甲基-3a,5,6,6a-四氢呋喃并[4,5-d][1,3]二氧杂环戊烯-6-基] 丁酸酯
反应条件
1: 90 percent / TEA / toluene / 4 h / Ambient temperature 2: 80 percent / 0.2 N H2SO4 / aq. ethanol / 50 °C View Scheme
参考文献
Catelani; Osti; Bianchi; Bergonzi; D'Andrea; Gambari
Bioorganic and medicinal chemistry letters, 1999 , vol. 9, # 21 p. 3153 - 3158
→
125161-47-9[(3aR,5R,6S,6aR)-5-[(1R)-1,2-二羟基乙基]-2,2-二甲基-3a,5,6,6a-四氢呋喃并[4,5-d][1,3]二氧杂环戊烯-6-基] 丁酸酯
反应条件
water; sulfuric acid in ethanol T=50°C; other catalyst concentration; Rate constant;
参考文献
Goueth, Pierre Y.; Gogalis, Pascalis; Bikanga, Raphael; Gode, Paul; Postel, Denis; et al.
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 2 p. 249 - 272
