5-(吖啶-9-基氨基)-N-[4-[二(2-氯乙基)氨基]苯基]戊酰胺合成路线 （共 5 条）
反应条件
in methanol T=20°C; 24 h;
参考文献
Gourdie; Valu; Gravatt; Boritzki; Baguley; Wakelin; Wilson; Woodgate; Denny
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1177 - 1186
反应条件
1: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 30 min, 2.) 20 deg C, 10 h 2: 25 percent / SOCl2 / 1,2-dichloro-ethane / 0.5 h / Heating 3: HBr/AcOH / 4 h / 20 °C 4: 75 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Gourdie; Valu; Gravatt; Boritzki; Baguley; Wakelin; Wilson; Woodgate; Denny
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1177 - 1186
反应条件
1: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 30 min, 2.) 20 deg C, 10 h 2: 25 percent / SOCl2 / 1,2-dichloro-ethane / 0.5 h / Heating 3: HBr/AcOH / 4 h / 20 °C 4: 75 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Gourdie; Valu; Gravatt; Boritzki; Baguley; Wakelin; Wilson; Woodgate; Denny
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1177 - 1186
反应条件
1: HBr/AcOH / 4 h / 20 °C 2: 75 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Gourdie; Valu; Gravatt; Boritzki; Baguley; Wakelin; Wilson; Woodgate; Denny
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1177 - 1186
反应条件
1: 25 percent / SOCl2 / 1,2-dichloro-ethane / 0.5 h / Heating 2: HBr/AcOH / 4 h / 20 °C 3: 75 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Gourdie; Valu; Gravatt; Boritzki; Baguley; Wakelin; Wilson; Woodgate; Denny
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1177 - 1186
