1: 86 percent / ethyl acetate / 6 h / Ambient temperature 3: 1.) hydrogen, 2.) MnO2 / 1.) Pd(OH)2 on carbon / 1.) ethyl acetate, 15 h, 50 psi, 2.) CH2Cl2, 30 min 4: 95 percent / aq. NaOH / 0.5 h / Ambient temperature 5: 92 percent / Et3N / ethyl acetate / 2 h / Heating View Scheme

1: 86 percent / ethyl acetate / 6 h / Ambient temperature 3: 1.) hydrogen, 2.) MnO2 / 1.) Pd(OH)2 on carbon / 1.) ethyl acetate, 15 h, 50 psi, 2.) CH2Cl2, 30 min 4: 95 percent / aq. NaOH / 0.5 h / Ambient temperature 5: 87 percent / 2.) Et3N / CH2Cl2 / 1.) 30 min, 2.) 30 min 6: 53 percent / aq. NaOH / Ra-Ni / 0.17 h / Heating View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 76 percent / Ti(OiPr)4 / 16 h / 120 - 130 &deg;C<br />2: 96 percent / MnO₂ / CH₂Cl₂ / 0.17 h / Ambient temperature<br /> <br /> &nbsp;