1: 2-Chloro-2-methylpropane With magnesium in tetrahydrofuran; cyclohexane 2: 7α-acetyl-17-(cyclopropylmethyl)-3-[(ethoxycarbonyl)oxy]-6,14-endo(ethano)tetrahydronororipavine in cyclohexane; toluene T=20°C;
参考文献
BROCK UNIVERSITY; HUDLICKY, Tomas; CARROLL, Robert; LEISCH, Hannes; MACHARA, Ales; WERNER, Lukas; ADAMS, David R.
Patent: WO2010/121369 A1, 2010 ;
Location in patent: Page/Page column 77-79 ;
1: 2-Chloro-2-methylpropane With magnesium in tetrahydrofuran; cyclohexane 2: 7α-acetyl-17-(cyclopropylmethyl)-3-[(ethoxycarbonyl)oxy]-6,14-endo(ethano)tetrahydronororipavine in cyclohexane; toluene T=20°C;
参考文献
BROCK UNIVERSITY; HUDLICKY, Tomas; CARROLL, Robert; LEISCH, Hannes; MACHARA, Ales; WERNER, Lukas; ADAMS, David R.
Patent: WO2010/121369 A1, 2010 ;
Location in patent: Page/Page column 77-79 ;
1: in tetrahydrofuran; hexane; cyclohexane; toluene T=20°C; Grignard reaction; 0.583333 h; Inert atmosphere; 2: With water in tetrahydrofuran; hexane; cyclohexane; toluene T=20°C; Further stages;
参考文献
Werner, Lukas; MacHara, Ales; Adams, David R.; Cox, D. Phillip; Hudlicky, Tomas
Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4628 - 4634
