反应条件
1: 4-iodo-1-triphenylmethyl-1H-imidazole With ethylmagnesium bromide in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.166667 h; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran Negishi coupling reaction; 2 h; Inert atmosphere; 3: 2',3',5'-tri-O-TBS-7-iodotubercidin With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=90°C; Negishi coupling reaction; 16 h; Inert atmosphere;
参考文献
Bourderioux, Aurelie; Naus, Petr; Perlikova, Pavla; Pohl, Radek; Pichova, Iva; Votruba, Ivan; Dzubak, Petr; Konecny, Petr; Hajduch, Marian; Stray, Kirsten M.; Wang, Ting; Ray, Adrian S.; Feng, Joy Y.; Birkus, Gabriel; Cihlar, Tomas; Hocek, Michal
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5498 - 5507