sodium hydroxide in methanol 8 h; Heating;

1: 86 percent / conc. H2SO4 / CH2Cl2 / 8 h / Ambient temperature 2: 86 percent / Et3N, 4-(N,N-dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature 3: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane 4: 99 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature 5: 79 percent / 2 N NaOH / methanol / 8 h / Heating View Scheme

1: 86 percent / conc. H2SO4 / CH2Cl2 / 8 h / Ambient temperature 2: 86 percent / Et3N, 4-(N,N-dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature 3: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane 4: 99 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature 5: 79 percent / 2 N NaOH / methanol / 8 h / Heating View Scheme

1: 86 percent / Et3N, 4-(N,N-dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature 2: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane 3: 99 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature 4: 79 percent / 2 N NaOH / methanol / 8 h / Heating View Scheme

1: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane 2: 99 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature 3: 79 percent / 2 N NaOH / methanol / 8 h / Heating View Scheme

1: 99 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature 2: 79 percent / 2 N NaOH / methanol / 8 h / Heating View Scheme