N-(4-溴-3-氯-2-甲基苯基)乙酰胺合成路线 （共 14 条）
反应条件
1-methyl-pyrrolidin-2-one; copper(l) iodide
T=130°C; 72 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/124447 A2, 2006 ;
Location in patent: Page/Page column 64-65 ;
WO 2006/124447 A2
反应条件
1: 67 percent / dimethylformamide / 4 h / 150 °C
2: 95 percent / conc. HCl; EtOH / 0.5 h / Heating
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/14627 A1, 2013 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=150°C; 4 h;
参考文献
Li, James J.; Hamann, Lawrence; Wang, Haixia
Patent: US2007/4717 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070004717 A1
反应条件
in N,N-dimethyl-formamide
T=150°C; 24 h;
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/14627 A1, 2013 ;
Location in patent: Page/Page column 45; 46 ;
