1.1: pyridine / dichloromethane; acetonitrile / 3 h / 50 °C 2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.75 h / |Cooling with ice 2.2: 5 h / 20 °C 3.1: sodium hydride / paraffin oil / 6.5 h / 20 °C 4.1: potassium tert-butylate / diethyl ether / 2 h / 40 - 45 °C / |Inert atmosphere 5.1: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 5 h / 20 °C 6.1: morpholine; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere; |Darkness 6.2: 0.3 h / 90 - 100 °C / |Inert atmosphere; |Darkness 7.1: sodium methylate; methanol / 1 h / 20 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.75 h / |Cooling with ice 1.2: 5 h / 20 °C 2.1: sodium hydride / paraffin oil / 6.5 h / 20 °C 3.1: potassium tert-butylate / diethyl ether / 2 h / 40 - 45 °C / |Inert atmosphere 4.1: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 5 h / 20 °C 5.1: morpholine; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere; |Darkness 5.2: 0.3 h / 90 - 100 °C / |Inert atmosphere; |Darkness 6.1: sodium methylate; methanol / 1 h / 20 °C View Scheme