1: 81 percent / 35percent ammonia / bis-(2-methoxy-ethyl) ether / Ambient temperature 2: 95 percent / thionyl chloride / dimethylformamide / Ambient temperature 3: 94 percent / aluminum chloride, sodium chloride / hexane; tetrahydrofuran / 1 h / 180 °C View Scheme

1: 81 percent / 35percent ammonia / bis-(2-methoxy-ethyl) ether / Ambient temperature 2: 95 percent / thionyl chloride / dimethylformamide / Ambient temperature View Scheme

1: With sodium azide in water; acetone T=20°C; 0.5 h; 2: in toluene 0.5 h; Heating; Further stages.;

ammonium hydroxide in diethylene glycol dimethyl ether Ambient temperature;

oxalyl dichloride; N,N-dimethyl-formamide in benzene Ambient temperature;

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C 1.2: 81 percent / 2 h / -78 - 20 °C 2.1: thionyl chloride / dimethylformamide / 2 h / Heating View Scheme

1.1: 100 percent / potasssium carbonate / acetone / 5 h / 40 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C 2.2: 81 percent / 2 h / -78 - 20 °C 3.1: thionyl chloride / dimethylformamide / 2 h / Heating View Scheme

1: 81 percent / 35percent ammonia / bis-(2-methoxy-ethyl) ether / Ambient temperature 2: 95 percent / thionyl chloride / dimethylformamide / Ambient temperature 3: 94 percent / aluminum chloride, sodium chloride / hexane; tetrahydrofuran / 1 h / 180 °C 4: 90 percent / cc. sulphuric acid / H2O; acetic acid / 48 h / Heating View Scheme