1: 1.) sodium methoxide / 1.) anhydrous methanol, nitrogen atmosphere, 0.5 h, 2.) anhydrous dimethylformamide, mild warming, 12 h 2: 2.33 g / 1N sodium hydroxide / 18 h / Ambient temperature View Scheme

Multi-step reaction with 3 steps 1: 2.60 g / H2 / 5percent palladium-on-charcoal / ethanol / 12 h / 2585.7 Torr2: triethylamine / diethyl ether / 4 h / 0 - 20 °C3: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h  

Multi-step reaction with 2 steps 1: triethylamine / diethyl ether / 4 h / 0 - 20 °C2: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h