6-羟基-8-[4-(嘧啶-2-基)-1-哌嗪基丁基]-8-氮杂螺[4,5]癸烷-7,9-二酮合成路线 （共 2 条）
反应条件
1: With sodium hexamethyldisilazane; triethyl phosphite in tetrahydrofuran T=-38 - -33°C; 2: With oxygen in tetrahydrofuran T=-40 - -28°C;
参考文献
WO2005/48954 A2, ;
Page/Page column 17-18 ;
反应条件
sodium hexamethyldisilazane; triethyl phosphite in tetrahydrofuran T=-60 - 20°C; Large scale;
参考文献
Organic Process Research and Development, , vol. 8, # 4 p. 616 - 623
