3-(环丙基甲基)-7-(4-苯基哌啶-1-基)-8-(三氟甲基)-[1,2,4]噻唑并[4,3-a]吡啶合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=180°C; 0.333333 h; Microwave irradiation;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8770 - 8789
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C 2.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / |Microwave irradiation 3.1: triethylamine / dichloromethane / 1 h / 20 °C 3.2: 150 °C / |Microwave irradiation 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 180 °C / |Microwave irradiation View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8770 - 8789
反应条件
1.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / |Microwave irradiation 2.1: triethylamine / dichloromethane / 1 h / 20 °C 2.2: 150 °C / |Microwave irradiation 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 180 °C / |Microwave irradiation View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8770 - 8789
反应条件
1.1: triethylamine / dichloromethane / 1 h / 20 °C 1.2: 150 °C / |Microwave irradiation 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 180 °C / |Microwave irradiation View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8770 - 8789
