反应条件
1.1: triethylamine / dichloromethane / 22.33 h / 0 - 20 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 20 h 2.2: pH ~ 12 3.1: sodium hydroxide / ethanol; water / 1.5 h / 60 °C 4.1: sodium hydroxide / ethanol; water / 0.67 h / 20 °C 5.1: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 1.5 h / 775.74 Torr View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.
Patent: WO2011/50202 A1, 2011 ;
WO 2011/050202 A1
