反应条件
Multi-step reaction with 3 steps 1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine / ethanol / 0.33 h / 140 °C / |Microwave irradiation2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C3: ChiralPak® AD-H / methanol; ethanol; dichloromethane / 25 °C / 75007.5 Torr / |Resolution of racemate
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn, P.; PASTERNAK, Alexander; DEJESUS, Reynalda, K.; TANG, Haifeng; PIO, Barbara; SHAHRIPOUR, Aurash; BELYK, Kevin, M.; CHOBANIAN, Harry, R.; GUO, Yan; FRIE, Jessica, L.; SHI, Zhi-Cai; CHEN, Helen; BLIZZARD, Timothy, A.; CATO, Brian Patent: WO2013/66714 A1, 2013 ;
