2-(4-氰基-3-甲氧基苯基)乙酸乙酯合成路线 （共 4 条）
反应条件
1: With lithium borohydride in tetrahydrofuran T=0°C; 12 h; 2: With water in tetrahydrofuran
参考文献
MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.
Patent: WO2010/129379 A1, 2010 ;
Location in patent: Page/Page column 55 ;
WO 2010/129379 A1
反应条件
1: ethyl (4-cyano-3-methoxyphenyl)acetate With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; mineral oil T=0°C; 1 h;
参考文献
MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.
Patent: WO2010/129379 A1, 2010 ;
Location in patent: Page/Page column 58 ;
WO 2010/129379 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; 4 h; Inert atmosphere;
参考文献
MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.
Patent: WO2010/129379 A1, 2010 ;
Location in patent: Page/Page column 55 ;
WO 2010/129379 A1
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 20 °C / |Inert atmosphere; |Cooling with acetone-dry ice
2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
