2-(4-氰基-3-甲氧基苯基)丙酸乙酯合成路线 （共 5 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 36 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45452 A1, 2013 ;
Location in patent: Page/Page column 52 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 36 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45447 A1, 2013 ;
Location in patent: Page/Page column 64 ;
反应条件
1: ethyl (4-cyano-3-methoxyphenyl)acetate With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; mineral oil T=0°C; 1 h;
参考文献
MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P.
Patent: WO2010/129379 A1, 2010 ;
Location in patent: Page/Page column 58 ;
WO 2010/129379 A1
反应条件
1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / -30 - 20 °C 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; ethanol / 15 h 3: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 4 h / 20 °C 4: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 36 h / 120 °C View Scheme
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45447 A1, 2013 ;
反应条件
1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / -30 - 20 °C 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; ethanol / 15 h 3: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 4 h / 20 °C 4: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 36 h / 120 °C View Scheme
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45447 A1, 2013 ;
