2-[[4-(5-乙基-4-嘧啶基)-1-哌嗪基]甲基]-6-(三氟甲基)-1H-苯并咪唑合成路线 （共 2 条）
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=80°C; 18 h;
参考文献
Pearce, Laura R.; Alton, Gordon R.; Richter, Daniel T.; Kath, John C.; Lingardo, Laura; Chapman, Justin; Hwang, Catherine; Alessi, Dario R.
Biochemical Journal, 2010 , vol. 431, # 2 p. 245 - 255
反应条件
1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 21 °C 1.2: 48 h / 21 °C 2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 21 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C View Scheme
参考文献
Biochemical Journal, , vol. 431, # 2 p. 245 - 255
