1.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C 1.2: 6 h / 0 - 20 °C 2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 0 - 20 °C 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C 4.1: (S)-(minus;)-1,1'-bi-2-naphthol; titanium (IV) isopropoxide / dichloromethane / 0.5 h / 20 °C / |Inert atmosphere; |Molecular sieve 4.2: 24 h / -78 - -20 °C / |Inert atmosphere; |Molecular sieve 5.1: 4-(N,N-dimethlyamino)pyridine / 1 h / 0 - 20 °C / |Inert atmosphere 6.1: Grubb's 2nd generation catalyst / dichloromethane 7.1: 0.5 h / 0 - 20 °C View Scheme

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C 2.1: R-(+)-proline / chloroform / 2 h / 0 °C 2.2: 2 h / 0 °C 3.1: acetic acid; zinc / ethanol / 12 h / 20 °C 4.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0 - 20 °C 5.1: lithium aluminium tetrahydride / tetrahydrofuran / |Reflux; |Inert atmosphere 6.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C 6.2: 6 h / 0 - 20 °C 7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 0 - 20 °C 8.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C 9.1: (S)-(minus;)-1,1'-bi-2-naphthol; titanium (IV) isopropoxide / dichloromethane / 0.5 h / 20 °C / |Inert atmosphere; |Molecular sieve 9.2: 24 h / -78 - -20 °C / |Inert atmosphere; |Molecular sieve 10.1: 4-(N,N-dimethlyamino)pyridine / 1 h / 0 - 20 °C / |Inert atmosphere 11.1: Grubb's 2nd generation catalyst / dichloromethane 12.1: 0.5 h / 0 - 20 °C View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C 1.2: 1 h / 0 - 20 °C 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C 3.1: R-(+)-proline / chloroform / 2 h / 0 °C 3.2: 2 h / 0 °C 4.1: acetic acid; zinc / ethanol / 12 h / 20 °C 5.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0 - 20 °C 6.1: lithium aluminium tetrahydride / tetrahydrofuran / |Reflux; |Inert atmosphere 7.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C 7.2: 6 h / 0 - 20 °C 8.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 0 - 20 °C 9.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C 10.1: (S)-(minus;)-1,1'-bi-2-naphthol; titanium (IV) isopropoxide / dichloromethane / 0.5 h / 20 °C / |Inert atmosphere; |Molecular sieve 10.2: 24 h / -78 - -20 °C / |Inert atmosphere; |Molecular sieve 11.1: 4-(N,N-dimethlyamino)pyridine / 1 h / 0 - 20 °C / |Inert atmosphere 12.1: Grubb's 2nd generation catalyst / dichloromethane 13.1: 0.5 h / 0 - 20 °C View Scheme