in water; acetonitrile T=20°C; 12 h;

in ethyl acetate Product distribution / selectivity;

1: sodium iodide; potassium carbonate / acetonitrile / 15 h / 80 °C / |Large scale 2: acetic acid / water 3: sodium hydroxide / ethanol / 15 h / 20 °C 4: acetonitrile / 15 h / 20 °C View Scheme

1.1: 5 h / 130 °C / |Large scale 1.2: 15 h / 80 °C / |Large scale 2.1: sodium iodide; potassium carbonate / acetonitrile / 15 h / 80 °C / |Large scale 3.1: acetic acid / water 4.1: sodium hydroxide / ethanol / 15 h / 20 °C 5.1: acetonitrile / 15 h / 20 °C View Scheme

1.1: triethylamine / dichloromethane / 1 h / -70 °C / |Large scale 1.2: 20 °C / |Large scale 2.1: 5 h / 130 °C / |Large scale 2.2: 15 h / 80 °C / |Large scale 3.1: sodium iodide; potassium carbonate / acetonitrile / 15 h / 80 °C / |Large scale 4.1: acetic acid / water 5.1: sodium hydroxide / ethanol / 15 h / 20 °C 6.1: acetonitrile / 15 h / 20 °C View Scheme

in water; acetonitrile T=20°C; 12 h;

in ethyl acetate Product distribution / selectivity;