4-甲氧基-2-氰基联苯合成路线 （共 32 条）
反应条件
1: boron tribromide / CH2Cl2 / 1.) -78 deg C - RT, 2.) RT, overnight 2: 48 percent / tri-n-butyltin azide / xylene / 1.) 120 deg C, 60 h, 2.) 130 deg C, 4 h View Scheme
参考文献
Kyoung Soon Kim; Qian; Bird; Dickinson; Moreland; Schaeffer; Waldron; Delaney; Weller; Miller
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2335 - 2342
反应条件
dichloro bis(acetonitrile) palladium(II); water; silver trifluoroacetate in N,N-dimethyl acetamide; trifluoroacetic acid T=140°C; Heck Reaction; 72 h; GloveboxInert atmosphere;
参考文献
Wan, Jung-Chih; Huang, Jun-Min; Jhan, Yu-Huei; Hsieh, Jen-Chieh
Organic Letters, 2013 , vol. 15, # 11 p. 2742 - 2745
反应条件
potassium phosphate; [5-(3-butylbenzimidazol-2-yliden-1-yl)-25,26,27,28-tetrapropyloxy calix[4]arene] (pyridine) palladium(II) dibromide in 1,4-dioxane
T=100°C; 24 h; Inert atmosphere;
参考文献
Ren, Hui; Xu, Yong; Jeanneau, Erwann; Bonnamour, Isabelle; Tu, Tao; Darbost, Ulrich
Tetrahedron, 2014 , vol. 70, # 17 p. 2829 - 2837
反应条件
1: 2-cyanophenyl bromide With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran
T=25°C; 0.5 h;
2: para-iodoanisole With zinc(II) chloride in tetrahydrofuran
0.25 h;
3: With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=25°C; Negishi coupling reaction; 3 h;
参考文献
Piller, Fabian M.; Appukkuttan, Prasad; Gavryushin, Andrei; Helm, Matthew; Knochel, Paul
Angewandte Chemie - International Edition, 2008 , vol. 47, # 36 p. 6802 - 6806
反应条件
1: p-methoxy-phenylmagnesium chloride With 2-iodo-propane in tetrahydrofuran
T=25°C; 0.0833333 h; Inert atmosphere;
2: 2-cyanophenyl bromide With PEPPSITM-IPr in tetrahydrofuran
T=25°C; Kumada coupling reaction; 0.0833333 h; Inert atmosphere;
参考文献
Manolikakes, Georg; Knochel, Paul
Angewandte Chemie - International Edition, 2009 , vol. 48, # 1 p. 205 - 209
反应条件
1: ortho-chloro-benzonitrile With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran
T=25°C; 0.75 h;
2: para-iodoanisole With zinc(II) chloride in tetrahydrofuran
0.25 h;
3: With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=25°C; Negishi coupling reaction; 3 h;
参考文献
Piller, Fabian M.; Appukkuttan, Prasad; Gavryushin, Andrei; Helm, Matthew; Knochel, Paul
Angewandte Chemie - International Edition, 2008 , vol. 47, # 36 p. 6802 - 6806
反应条件
1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride in tetrahydrofuran
T=160°C; Negishi cross-coupling; 0.05 h; microwave irradiation;
参考文献
Walla, Peter; Kappe, C. Oliver
Chemical Communications, 2004 , # 5 p. 564 - 565
反应条件
n-butyllithium; Zinc chloride in tetrahydrofuran; hexane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US6117885 A1, 2000 ;
反应条件
n-butyllithium; Zinc chloride; tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran; hexane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5380719 A1, 1995 ;
反应条件
manganese (II) chloride in tetrahydrofuran
T=0°C; Substitution; Cross-coupling reaction; 2 h;
参考文献
Cahiez, Gerard; Lepifre, Franck; Ramiandrasoa, Parfait
Synthesis, 1999 , # 12 p. 2138 - 2144
