4-甲氧基-2-氰基联苯合成路线 （共 32 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); KF dihydrate; [HP(t-Bu)3]BF4 in tetrahydrofuran
T=20°C; Suzuki cross-coupling; Inert atmosphere;
参考文献
Zhao, Yu-Long; Li, You; Li, Shui-Ming; Zhou, Yi-Guo; Sun, Feng-Yi; Gao, Lian-Xun; Han, Fu-She
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1543 - 1550
反应条件
potassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Han, Fu-She
European Journal of Organic Chemistry, 2012 , # 19 p. 3575 - 3579
反应条件
1: benzonitrile With TMP2Mg*2LiCl in tetrahydrofuran
T=-30°C; 3 h; Inert atmosphere;
2: para-iodoanisole With tri-2-furyl phosphite; zinc(II) chloride; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=-40 - 25°C; Negishi coupling reaction; Inert atmosphere; chemoselective reaction;
参考文献
Rohbogner, Christoph J.; Wunderlich, Stefan H.; Clososki, Giuliano C.; Knochel, Paul
European Journal of Organic Chemistry, 2009 , # 11 p. 1781 - 1795
反应条件
manganese (II) chloride in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Zhang, Line; Ang, Gim Yean; Chiba, Shunsuke
Organic Letters, 2010 , vol. 12, # 16 p. 3682 - 3685
反应条件
palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene
T=120°C; 24 h; Sealed tubeInert atmosphere;
参考文献
Zhou, Chao; Liu, Qingjiang; Li, Yaming; Zhang, Rong; Fu, Xinmei; Duan, Chunying
Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10468 - 10472
反应条件
triphenylphosphine in tetrahydrofuran; water
参考文献
Great Lakes Chemical Konstanz GmbH
Patent: US6121480 A1, 2000 ;
反应条件
pyridine; tetra-n-butylammonium tetrafluoroborate in acetonitrile
T=20°C; Electrolysisiron rod as anode; stainless steel grid as cathode;
参考文献
Gomes, Paulo; Fillon, Hyacinthe; Gosmini, Corinne; Labbe, Eric; Perichon, Jacques
Tetrahedron, 2002 , vol. 58, # 42 p. 8417 - 8424
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.25 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
K3PO4; Pd(PPh3)2Cl2 in toluene
T=100°C; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Wan, Jung-Chih; Huang, Jun-Min; Jhan, Yu-Huei; Hsieh, Jen-Chieh
Organic Letters, 2013 , vol. 15, # 11 p. 2742 - 2745
反应条件
palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene
T=120°C; 40 h; Inert atmosphereSealed tube;
参考文献
Zhou, Chao; Li, Yaming; Lu, Yang; Zhang, Rong; Jin, Kun; Fu, Xinmei; Duan, Chunying
Chinese Journal of Chemistry, 2013 , vol. 31, # 10 p. 1269 - 1273
