4-甲氧基-2-氰基联苯合成路线 （共 32 条）
反应条件
1-(4-methoxyphenyl)ethanone in tert-butyl alcohol
3 h; Inert atmosphereUV-irradiation;
参考文献
McBurney, Roy T.; Slawin, Alexandra M. Z.; Smart, Laura A.; Yu, Yanping; Walton, John C.
Chemical Communications, 2011 , vol. 47, # 28 p. 7974 - 7976
反应条件
palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene
T=120°C; 40 h; Inert atmosphereSealed tube;
参考文献
Zhou, Chao; Li, Yaming; Lu, Yang; Zhang, Rong; Jin, Kun; Fu, Xinmei; Duan, Chunying
Chinese Journal of Chemistry, 2013 , vol. 31, # 10 p. 1269 - 1273
反应条件
in benzene
Ambient temperature;
参考文献
Sain, Bir; Sandhu, Jagir S.
Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2545 - 2546
反应条件
in tetrahydrofuran
T=0°C; 2.25 h; Inert atmosphere;
参考文献
Anbarasan, Pazhamalai; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2010 , vol. 16, # 16 p. 4725 - 4728
反应条件
bathophenanthroline; sodium t-butanolate
T=182°C; 6 h; Inert atmosphere;
参考文献
Shirakawa, Eiji; Itoh, Ken-Ichi; Higashino, Tomohiro; Hayashi, Tamio
Journal of the American Chemical Society, 2010 , vol. 132, # 44 p. 15537 - 15539
反应条件
1: toluene / 2 h / 110 °C
2: Pd(PPh3)2Cl2; K3PO4 / toluene / 12 h / 100 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Wan, Jung-Chih; Huang, Jun-Min; Jhan, Yu-Huei; Hsieh, Jen-Chieh
Organic Letters, 2013 , vol. 15, # 11 p. 2742 - 2745
反应条件
1.1: magnesium; 1,2-dibromoethane / tetrahydrofuran / 0.25 h / 180 °C / microwave irradiation
2.1: ZnCl2; TMEDA / tetrahydrofuran / 0.25 h / 80 °C / microwave irradiation
2.2: 92 percent / Pd(PPh3)2Cl2 / tetrahydrofuran / 0.03 h / 120 °C / microwave irradiation
View Scheme
参考文献
Mutule, Ilga; Suna, Edgars
Tetrahedron, 2005 , vol. 61, # 47 p. 11168 - 11176
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol / 18 h / Reflux
2: pyridine / dichloromethane / 18 h / 20 °C
3: 1-(4-methoxyphenyl)ethanone / α,α,α-trifluorotoluene / 3 h / Inert atmosphere; UV-irradiation
View Scheme
参考文献
McBurney, Roy T.; Slawin, Alexandra M. Z.; Smart, Laura A.; Yu, Yanping; Walton, John C.
Chemical Communications, 2011 , vol. 47, # 28 p. 7974 - 7976
反应条件
1: pyridine / dichloromethane / 18 h / 20 °C
2: 1-(4-methoxyphenyl)ethanone / α,α,α-trifluorotoluene / 3 h / Inert atmosphere; UV-irradiation
View Scheme
参考文献
McBurney, Roy T.; Slawin, Alexandra M. Z.; Smart, Laura A.; Yu, Yanping; Walton, John C.
Chemical Communications, 2011 , vol. 47, # 28 p. 7974 - 7976
反应条件
1: potassium phosphate / toluene; water / 0.5 h / 0 - 20 °C
2: 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate / toluene / 24 h / 120 °C / |Sealed tube; |Inert atmosphere
View Scheme
参考文献
Zhou, Chao; Liu, Qingjiang; Li, Yaming; Zhang, Rong; Fu, Xinmei; Duan, Chunying
Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10468 - 10472
