ammonia in methanol 18 h; Ambient temperature;

Multi-step reaction with 5 steps 1: HCl / 0.25 h / Ambient temperature2: 40 percent / pyridine / 4 h / 0 °C3: 76 percent / 4-(dimethylamino)pyridine / acetonitrile; CH2Cl2 / 4 h / Ambient temperature4: 90 percent / bis(1-cyano-1-methylethyl)diazene, tributyltinhydride / toluene / 3 h / 80 °C5: 29 percent / trimethylsilyl triflate / acetonitrile / 2.5 h / -30 °C  

Multi-step reaction with 3 steps 1: 76 percent / 4-(dimethylamino)pyridine / acetonitrile; CH2Cl2 / 4 h / Ambient temperature2: 90 percent / bis(1-cyano-1-methylethyl)diazene, tributyltinhydride / toluene / 3 h / 80 °C3: 29 percent / trimethylsilyl triflate / acetonitrile / 2.5 h / -30 °C  

Multi-step reaction with 3 steps 1: 86 percent / 4-(dimethylamino)pyridine / acetonitrile; CH2Cl2 / 4 h / Ambient temperature2: 80 percent / bis(1-cyano-1-methylethyl)diazene, tributyltinhydride / toluene / 3 h / 80 °C3: 29 percent / trimethylsilyl triflate / acetonitrile / 2.5 h / -30 °C  

Multi-step reaction with 2 steps 1: 90 percent / bis(1-cyano-1-methylethyl)diazene, tributyltinhydride / toluene / 3 h / 80 °C2: 29 percent / trimethylsilyl triflate / acetonitrile / 2.5 h / -30 °C