(R,S)-1-甲基-3-烟酰吡咯烷酮合成路线 （共 6 条）
反应条件
sodium hydride in toluene; mineral oil 30 h; Reflux;
参考文献
TOPHARMAN SHANGHAI CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; Tian, Guanghui; Wang, Guan; Kong, Xiaoguang; Zhang, Rongxia; Chen, Weiming; Shen, Jingshan
Patent: US2014/31554 A1, 2014 ;
Location in patent: Paragraph 0045; 0046 ;
反应条件
1: sulfuric acid / 4 h / 85 °C 2: sodium hydride / toluene; mineral oil / 30 h / |Reflux View Scheme
反应条件
sodium ethanolate; benzene Erhitzen auf Siedetemperatur;
参考文献
Chemische Berichte, , vol. 61, p. 330
反应条件
hydrogenchloride T=130 - 140°C;
参考文献
Spaeth et al.
Chemische Berichte, 1938 , vol. 71, p. 100,105
Full Text Show Details
Korte; Schulze-Steinen
Chemische Berichte, 1962 , vol. 95, p. 2444,2450
反应条件
hydrogenchloride 72 h; Heating;
参考文献
Pathak, Tanmaya; Thomas, Noel F.; Akhtar, Mahmoud; Gani, David
Tetrahedron, 1990 , vol. 46, # 5 p. 1733 - 1744
反应条件
1: With hydrogenchloride T=135°C; 40 h; 2: With sodium tetrahydroborate; sodium hydroxide pH=8; 1.5 h; Cooling with ice; ConcentrationReagent/catalystTimeTemperature;
参考文献
TOPHARMAN SHANGHAI CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; Tian, Guanghui; Wang, Guan; Kong, Xiaoguang; Zhang, Rongxia; Chen, Weiming; Shen, Jingshan
Patent: US2014/31554 A1, 2014 ;
Location in patent: Paragraph 0038 ;
