1-叔丁基吡唑-4-硼酸频那醇酯合成路线 （共 4 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane 15 h; Reflux;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 104; 105 ;
反应条件
1: 4-bromo-1-(1,1-dimethylethyl)-1H-pyrazole With n-butyllithium in tetrahydrofuran T=-85 - -75°C; 1 h; Industry scale; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran 3 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED; Atkinson, Francis Louis; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander George Steven; Wilson, David Matthew
Patent: US2013/40984 A1, 2013 ;
Location in patent: Paragraph 0484-0485 ;
反应条件
1.1: N-bromosuccinmide / dichloromethane / 18 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran / -85 - -78 °C / |Large scale 2.2: 0.3 h / |Large scale View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
反应条件
1.1: 90 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / -85 - -75 °C / Industry scale 2.2: 3 h View Scheme
参考文献
GLAXO GROUP LIMITED; Atkinson, Francis Louis; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander George Steven; Wilson, David Matthew
Patent: US2013/40984 A1, 2013 ;
