3-乙酰氨基-4-甲氧基苯硼酸频那醇酯合成路线 （共 3 条）
反应条件
potassium acetate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in ethylene glycol dimethyl ether T=150°C;
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
Location in patent: Page/Page column 202 ;
WO 2011/095625 A1
反应条件
1.1: triethylamine / dichloromethane / 0.08 h / 10 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 70 °C 2.2: 16 h / 60 °C 3.1: potassium acetate / triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / ethylene glycol dimethyl ether / 150 °C View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
WO 2011/095625 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 70 °C 1.2: 16 h / 60 °C 2.1: potassium acetate / triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / ethylene glycol dimethyl ether / 150 °C View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
WO 2011/095625 A1
