(S)-4-苯基-2-羟基丁酸乙酯合成路线 （共 35 条）
反应条件
1: With (DHQD)2AQN in diethyl ether T=-78°C; 24 h; 2: With water Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 12 p. 2870 - 2871
反应条件
1.1: 63 percent / H2; iso-cinchonine / 5 percent Pt/Al2O3 / toluene / 1.5 h / 25 °C / 45003.6 Torr 2.1: HCl; H2 / 5 percent Pd/C / ethanol / 11.5 h / 25 °C / 825.07 Torr 2.2: 98 percent / HCl / 24 h / 20 °C View Scheme
参考文献
Synthesis, , # 11 p. 1679 - 1682
反应条件
sulfuric acid 5 h; Inert atmosphereReflux;
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
1: (E)-2-oxo-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=70°C; P=20686.5 Torr; 20 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: (E)-2-oxo-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 10 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: D-(+)-glucose; ammonium hydroxide / aq. buffer / 24 h / 30 °C / pH 4 2: sodium acetate; 5 palladium on charcoal / ethanol / 2 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 3 p. 611 - 617
反应条件
1: 1) LDA / 1) THF, -55 deg C 2: 92 percent / Swern oxidation 3: 69 percent / NaBH4 / ethanol / -60 °C 4: 92 percent / xylene / 0.25 h / Heating 5: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
1: 88 percent / diisobutylaluminum hydride / diethyl ether / -60 °C 2: 92 percent / Swern oxidation 3: 69 percent / NaBH4 / ethanol / -60 °C 4: 92 percent / xylene / 0.25 h / Heating 5: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen T=90°C; P=20686.5 Torr; 20 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: 90 percent / Candida parapsilopsis ATCC 7330 / ethanol; H2O / 1 h / 25 °C / Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 14 p. 1461 - 1464
