(S)-4-苯基-2-羟基丁酸乙酯合成路线 （共 35 条）
反应条件
1: 90 percent / Candida parapsilopsis ATCC 7330 / ethanol; H2O / 1 h / 25 °C / Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 14 p. 1461 - 1464
反应条件
1: 94 percent / H2; AcOH / Pd/C / 20 °C / 760 Torr 2: 95 percent / H2SO4 / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
1: 72 percent / AlCl3 / 4 h / Heating 2: 94 percent / H2; AcOH / Pd/C / 20 °C / 760 Torr 3: 95 percent / H2SO4 / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
1: 92 percent / Swern oxidation 2: 69 percent / NaBH4 / ethanol / -60 °C 3: 92 percent / xylene / 0.25 h / Heating 4: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
1: 92 percent / xylene / 0.25 h / Heating 2: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
1: (+/-)-2-hydroxy-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran P=20686.5 Torr; 5 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 2: [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen / tetrahydrofuran; water / 20 h / 70 °C / 20686.5 Torr / Autoclave 3: sulfuric acid / 5 h / Inert atmosphere; Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
1.1: magnesium / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 1.2: 1.5 h / -10 °C / Inert atmosphere 1.3: Inert atmosphere 2.1: lithium hydroxide hydrate / ethanol / 1 h / Cooling with ice; Inert atmosphere 3.1: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 4.1: [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen / tetrahydrofuran; water / 20 h / 70 °C / 20686.5 Torr / Autoclave 5.1: sulfuric acid / 5 h / Inert atmosphere; Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
1: [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen / tetrahydrofuran; water / 20 h / 70 °C / 20686.5 Torr / Autoclave 2: sulfuric acid / 5 h / Inert atmosphere; Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
dimethylsulfide; ozone 1) -65 deg C, 2) r.t.; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
