1: β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=20°C; 0.583333 h; 2: (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester in tetrahydrofuran T=20°C; optical yield given as percent de;

1.1: di-isopropyl ether / -10 °C / Resolution of racemate 2.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / 21 h / 20 - 50 °C 2.2: 60.25 h / 20 °C View Scheme