5-氟-3-甲基吡啶-2-羧酸合成路线 （共 3 条）
反应条件
1: With lithium hydroxide hydrate; water in methanol T=22°C; 16 h; 2: With hydrogenchloride in water pH=1;
参考文献
Banner, David; Guba, Wolfgang; Hilpert, Hans; Humm, Roland; Mauser, Harald; Mayweg, Alexander V.; Narquizian, Robert; Power, Eoin; Rogers-Evans, Mark; Rombach, Didier; Woltering, Thomas; Wostl, Wolfgang
Patent: US2011/312937 A1, 2011 ;
Location in patent: Page/Page column 82 ;
反应条件
1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 20 h / 110 °C / 75007.5 Torr 2.1: water; lithium hydroxide hydrate / methanol / 16 h / 22 °C 2.2: pH 1 View Scheme
参考文献
Banner, David; Guba, Wolfgang; Hilpert, Hans; Humm, Roland; Mauser, Harald; Mayweg, Alexander V.; Narquizian, Robert; Power, Eoin; Rogers-Evans, Mark; Rombach, Didier; Woltering, Thomas; Wostl, Wolfgang
Patent: US2011/312937 A1, 2011 ;
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.5 h / 120 °C / microwave irradiation 2.1: hydrogenchloride; water / 2 h / 120 °C / Sealed tube 2.3: pH 2 View Scheme
参考文献
NOVARTIS AG; HURTH, Konstanze; LUEOEND, Rainer Martin; MACHAUER, Rainer; NEUMANN, Ulf; RUEEGER, Heinrich; SCHAEFER, Michael; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus
Patent: WO2012/95463 A1, 2012 ;
