4-溴-2-碘-1-(三氟甲基)苯合成路线 (共 1 条)
反应条件
1: With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran T=-78 - 20°C; 0.666667 h; 2: With iodine; potassium iodide in acetone T=0 - 20°C; 1 h;
参考文献
LEO PHARMA A/S
Patent: US2012/129926 A1, 2012 ;
Location in patent: Page/Page column 21 ;