4-(羟基甲基)苯甲醛乙酸二乙酯合成路线 （共 8 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran T=20°C; 1.5 h;
参考文献
LIGHTSHIP MEDICAL LIMITED; JAMES, Tony; BARWELL, Nicholas, Paul
Patent: WO2012/95628 A1, 2012 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1.1: hydrogenchloride; water / tetrahydrofuran / 1 h 2.1: hydrogen bromide / dichloromethane; acetic acid 3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 5.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 5.2: Heating View Scheme
参考文献
LIGHTSHIP MEDICAL LIMITED; JAMES, Tony; BARWELL, Nicholas, Paul
Patent: WO2012/95628 A1, 2012 ;
反应条件
water; hydrogen bromide 1 h; Reflux;
参考文献
Mateus, Pedro; Delgado, Rita; Groves, Patrick; Campos, Sara R. R.; Baptista, Antonio M.; Brandao, Paula; Felix, Vitor
Journal of Organic Chemistry, 2012 , vol. 77, # 16 p. 6816 - 6824
反应条件
hydrogenchloride; water in tetrahydrofuran 1 h;
参考文献
LIGHTSHIP MEDICAL LIMITED; JAMES, Tony; BARWELL, Nicholas, Paul
Patent: WO2012/95628 A1, 2012 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: 70 percent / triethylamine; DMAP / CH2Cl2 / 4 h / 20 °C 2: 76 percent / BiNO3-5H2O / CH2Cl2 / 0.75 h / 20 °C View Scheme
参考文献
Eash; Pulia; Wieland; Mohan
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8399 - 8401
反应条件
1.1: hydrogenchloride; water / tetrahydrofuran / 1 h 2.1: hydrogen bromide / dichloromethane; acetic acid 3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 5.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 5.2: Heating 6.1: chloroform / Inert atmosphere View Scheme
参考文献
LIGHTSHIP MEDICAL LIMITED; JAMES, Tony; BARWELL, Nicholas, Paul
Patent: WO2012/95628 A1, 2012 ;
反应条件
1.1: hydrogenchloride; water / tetrahydrofuran / 1 h 2.1: hydrogen bromide / dichloromethane; acetic acid 3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C 5.1: triphenylphosphine / tetrahydrofuran / 1 h / 60 °C 5.2: Heating 6.1: chloroform / Inert atmosphere 7.1: manganese(IV) oxide / dichloromethane / 3 h View Scheme
参考文献
LIGHTSHIP MEDICAL LIMITED; JAMES, Tony; BARWELL, Nicholas, Paul
Patent: WO2012/95628 A1, 2012 ;
反应条件
1: 100 percent / pyridine
2: 36.5 g / conc. H2SO4 / tetrahydrofuran; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Onodera, Akira; Tomisawa, Kazuyuki; Yamashita, Miyuki; Takeshita, Kimiyo; Yokomori, Sadakazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 8 p. 2713 - 2721
