3-(吡啶-2-基氧基)丙烷-1-胺合成路线 (共 2 条)
反应条件
1: 3-amino-propan-1-ol With sodium hydride in tetrahydrofuran T=20°C; 0.583333 h; Heating / reflux; 2: 2-bromo-pyridine in tetrahydrofuran T=20°C; 20.3333 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2006/73366 A1, 2006 ;
Location in patent: Page/Page column 186 ;
WO 2006/073366 A1
反应条件
sodium hydride 1.) THF, reflux, 1 h; 2.) reflux, 2.5 h; Yield given. Multistep reaction;
参考文献
Ife; Catchpole; Durant; Ganellin; Harvey; Meeson; Owen; Parsons; Slingsby; Theobald
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 3 p. 249 - 258