1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; bis(triphenylphosphine)palladium(II)-chloride in N,N-dimethyl-formamide T=140°C; 8 h;

2: 90 percent / 4N HCl / tetrahydrofuran / 3 h / Heating 3: 82 percent / 2,6-lutidine / CH2Cl2 / 1 h / -30 - 0 °C 4: 72 percent / LiCl, DBU / bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 8 h / 140 °C View Scheme

2: 90 percent / 4N HCl / tetrahydrofuran / 3 h / Heating 3: 82 percent / 2,6-lutidine / CH2Cl2 / 1 h / -30 - 0 °C 4: 72 percent / LiCl, DBU / bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 8 h / 140 °C View Scheme

1: 82 percent / 2,6-lutidine / CH2Cl2 / 1 h / -30 - 0 °C 2: 72 percent / LiCl, DBU / bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 8 h / 140 °C View Scheme

1: 90 percent / 4N HCl / tetrahydrofuran / 3 h / Heating 2: 82 percent / 2,6-lutidine / CH2Cl2 / 1 h / -30 - 0 °C 3: 72 percent / LiCl, DBU / bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 8 h / 140 °C View Scheme

1: diisopropylethylamine / CH2Cl2 / 0 °C 3: 4 N HCl / tetrahydrofuran / 2 h / Heating 4: 2,6-lutidine / CH2Cl2 / 1 h / -30 °C 5: 72 percent / LiCl, DBU / Pd(PPh3)2Cl2 / dimethylformamide / 6 h / 135 - 140 °C View Scheme