(5S,5aS,8aR,9R)-5-[(4-氟苯基)氨基]-9-(4-羟基-3,5-二甲氧基-苯基)-5a,6,8a,9-四氢-5H-异苯并呋喃并[5,6-f][1,3]苯并二氧戊环-8-酮合成路线 （共 7 条）
反应条件
tetra-(n-butyl)ammonium iodide; triethylamine in tetrahydrofuran T=25 - 35°C; 6 h;
参考文献
Tetrahedron Letters, , vol. 37, # 19 p. 3359 - 3362
反应条件
barium carbonate in dichloromethane Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1364 - 1368
反应条件
1: HBr / CH2Cl2; diethyl ether / 0.75 h / 0 °C 2: 72 percent / Et3N, Bu4N(1+)*I(1-) / tetrahydrofuran / 6 h / 25 - 35 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 19 p. 3359 - 3362
反应条件
barium carbonate in tetrahydrofuran T=20°C; Substitution; 8 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 18 p. 2059 - 2062
反应条件
1: BF3*OEt2; NaI / CH2Cl2 / 5 h / 20 °C 2: BaCO3 / tetrahydrofuran / 8 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 46 p. 8457 - 8459
反应条件
1: BaCO3 / acetone; H2O / 1.5 h / 40 °C 2: HBr / CH2Cl2; diethyl ether / 0.75 h / 0 °C 3: 72 percent / Et3N, Bu4N(1+)*I(1-) / tetrahydrofuran / 6 h / 25 - 35 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 19 p. 3359 - 3362
反应条件
trimethylsilyl iodide; barium carbonate 1.) CH2Cl2, 0 degC, 6 h; 2.) THF, r.t., 15 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 38, # 15 p. 2673 - 2676
