triethylamine in tetrahydrofuran; diethyl ether 20 h;

1: 1.00 g / methanol / 8 h / 20 °C 2: 99 percent / hydrogen / palladized charcoal / methanol; tetrahydrofuran / 1 h / 20 °C 3: NEt3 / CH2Cl2 / 0 - 20 °C View Scheme

1: 99 percent / hydrogen / palladized charcoal / methanol; tetrahydrofuran / 1 h / 20 °C 2: NEt3 / CH2Cl2 / 0 - 20 °C View Scheme

n-butyllithium; N,N,N',N,-tetramethylethylenediamine; iodine 1.) THF/hexane, -78 deg C, 15 min; -25 deg C, 2 h; 2.) THF, -78 deg C, 15 min; -25 deg C, 2 h;

1: N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether T=-10°C; 3 h; 2: carbon dioxide in diethyl ether 1 h; cooling; Further stages.;