1: 96 percent / HF, pyridine / tetrahydrofuran / 0.5 h / 0 °C 2: 95 percent / 1,3-dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP), camphorsulfonic acid (CSA) / CH2Cl2 / 4 h / 25 °C 3: 89 percent / HF, pyridine / tetrahydrofuran / 0 °C 4: 93 percent / H2 / 10percent Pd(OH)2/C / ethyl acetate / 2 h / Ambient temperature 5: 45 percent / triphenylphosphine, 2,2'-dipyridyl disulfide / toluene / 1.) 25 deg C, 3 h, 2.) reflux, 12 h View Scheme

1: 95 percent / H2 / 5 percent Pd/C 2: DMAP; DCC / CH2Cl2 / 24 h / 20 °C 3: TBAF / tetrahydrofuran / 48 °C View Scheme

hydrogen; palladium on activated charcoal Hydrogenolysis;

<b>Multi-step reaction with 2 steps<br /> </b>1: 87 percent / imidazole / dimethylformamide / 0.25 h / 25 &deg;C<br />2: 96 percent / K₂CO₃ / acetone / 1 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 87 percent / imidazole / dimethylformamide / 0.25 h / 25 &deg;C<br />2: 96 percent / K₂CO₃ / acetone / 1 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: 20 percent; aq. nBu₄NOH / 2 h / 65 &deg;C<br />1.2: 89 percent / dimethylformamide / 24 h<br />2.1: 92 percent / imidazole / dimethylformamide<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: 20 percent; aq. nBu₄NOH / 2 h / 65 &deg;C<br />1.2: 89 percent / dimethylformamide / 24 h<br />2.1: 92 percent / imidazole / dimethylformamide<br /> <br /> &nbsp;