8-(4-溴苯基)-1,4-二氧杂螺[4.5]癸烷-8-醇合成路线 （共 4 条）
反应条件
magnesium 1.) THF, reflux, 2.) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 59, # 7 p. 1855 - 1862
反应条件
toluene-4-sulfonic acid in toluene T=110°C; 4 h; Inert atmosphere;
参考文献
Dongjin Semichem Co., Ltd.,
Patent: US2011/237849 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
toluene-4-sulfonic acid in toluene
参考文献
Karl Thomae GmbH
Patent: US5541343 A1, 1996 ;
反应条件
1: KHSO4 / chlorobenzene / 12 h / Heating
2: 85percent acetic acid / 3 h / 100 °C
3: 56 percent / H2 / 5percent Rh/C / ethyl acetate / 6 h / 31028.9 Torr / Ambient temperature
View Scheme
参考文献
Zhang, Yifan; Schuster, Gary B.
Journal of Organic Chemistry, 1994 , vol. 59, # 7 p. 1855 - 1862
