(3R,5R)-6-氰基-3,5-二羟基己酸叔丁酯合成路线 (共 4 条)
反应条件
pyridinium p-toluenesulfonate in acetone T=20°C; 5 h;
参考文献
Kaneka Corporation
Patent: US6344569 B1, 2002 ;
Location in patent: Page column 13 ;
反应条件
methanesulfonic acid T=29 - 30°C; 3 - 4 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/90301 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
With D-glucose in water T=28°C; 24 - 48 h; Microbiological reaction; Show Experimental Procedure
参考文献
BIOCON LIMITED Patent: WO2006/131933 A1, 2006 ; Location in patent: Page/Page column 5-6 ;
反应条件
Multi-step reaction with 3 steps 2: AcOH, Bu4NF / tetrahydrofuran3: NaBH4, B(Et)2OMe / methanol / -90 °C
参考文献
Brower; Butler; Deering; Le; Millar; Nanninga; Roth Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2279 - 2282