(4R-cis)-6-氰甲基-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯合成路线 （共 25 条）
反应条件
pyridinium p-toluenesulfonate in acetone T=20°C; 5 h;
参考文献
Kaneka Corporation
Patent: US6344569 B1, 2002 ;
Location in patent: Page column 13 ;
反应条件
4-methyl-morpholine in toluene T=20°C; 12.5 h;
参考文献
WO2004/96788 A1, ;
Page 15 ;
反应条件
methanesulfonic acid T=29 - 30°C; 3 - 4 h;
参考文献
WO2005/90301 A1, ;
Page/Page column 13 ;
反应条件
sodium borohydride; acetic acid in tetrahydrofuran; methanol; water; ethyl acetate
反应条件
in dimethyl sulfoxide
参考文献
Brower; Butler; Deering; Le; Millar; Nanninga; Roth
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2279 - 2282
反应条件
in dimethyl sulfoxide
参考文献
Brower; Butler; Deering; Le; Millar; Nanninga; Roth
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2279 - 2282
反应条件
in dimethyl sulfoxide
参考文献
Brower; Butler; Deering; Le; Millar; Nanninga; Roth
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2279 - 2282
反应条件
1: hexane; tetrahydrofuran 2: NaBH4, B(Et)2OMe / methanol / -90 °C 3: MeSO3H View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 17 p. 2279 - 2282
反应条件
1: 95 percent / NEt3 / CH2Cl2 2: 90 percent / dimethylsulfoxide View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 17 p. 2279 - 2282
反应条件
2: AcOH, Bu4NF / tetrahydrofuran 3: NaBH4, B(Et)2OMe / methanol / -90 °C 4: MeSO3H View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 17 p. 2279 - 2282
