4-(氯甲基)-5H-呋喃-2-酮合成路线 （共 9 条）
反应条件
pyridine; thionyl chloride in dichloromethane T=20 - 25°C; 15 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 9 p. 2847 - 2855
反应条件
18-crown-6 ether; potassium chloride in acetonitrile T=40°C; 96 h;
参考文献
Tetrahedron, , vol. 50, # 23 p. 6839 - 6858
反应条件
tetrachloromethane; triphenylphosphine T=25°C; 72 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 9 p. 2847 - 2855
反应条件
sodium tetrahydroborate; nickel dichloride in methanol T=0°C; 0.5 h;
参考文献
Tetrahedron, , vol. 50, # 23 p. 6839 - 6858
反应条件
1: AlCl3, Cl2 / CH2Cl2 / 16 h / 20 - 25 °C 2: NEt3 / CH2Cl2 / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 9 p. 2847 - 2855
反应条件
N-bromosuccinmide in tetrachloromethane 0.5 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 55, # 9 p. 2847 - 2855
反应条件
1: AlCl3, Cl2 / CH2Cl2 / 16 h / 20 - 25 °C 2: NEt3 / CH2Cl2 / 0 °C 3: 450 mg / NBS / CCl4 / 0.58 h / Irradiation 4: silver acetate / acetone; H2O / 96 h View Scheme
参考文献
LaLonde, Robert T.; Perakyla, Hannu; Hayes, Michael P.
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2847 - 2855
反应条件
sodium tetrahydroborate; nickel dichloride in methanol
T=0°C; 0.5 h;
参考文献
Schroeer, Josef; Welzel, Peter
Tetrahedron, 1994 , vol. 50, # 23 p. 6839 - 6858
反应条件
1.1: 87 percent / Et3N / CH2Cl2 / 0 °C
2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 1 h / 0 °C
2.2: Li2CuCl4 / tetrahydrofuran / 0.33 h / 0 °C
3.1: 98 mg / Amberlyst-15; H20 / acetone / 0.75 h / 20 °C
View Scheme
参考文献
Boukouvalas, John; Robichaud, Joel; Maltais, Francois
Synlett, 2006 , # 15 p. 2480 - 2482
