反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1: sodium hydroxide / ethanol / 14 h / 20 °C<br />2: pyridine; thionyl chloride / N,N-dimethyl-formamide; chlorobenzene / 22 h / 120 °C<br />3: triethylamine / 12 h / Reflux<br />4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 13.5 h / 20 - 70 °C<br /> <br />
参考文献
Bravo-Altamirano, Karla; George, Kara M.; Frantz, Marie-Celine; Lavalle, Courtney R.; Tandon, Manuj; Leimgruber, Stephanie; Sharlow, Elizabeth R.; Lazo, John S.; Wang, Q. Jane; Wipf, Peter ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 2 p. 154 - 159
