5,5-二甲基-1,3-环己二酮合成路线 （共 504 条）
反应条件
1: anthranilic acid With hydrogenchloride; sodium hydroxide; sodium nitrite in water
T=-0.16 - 4.84°C; Japp-Klingemann reaction; 1 h; Cooling with ice;
2: dimedone With sodium hydroxide in water
T=-0.16°C; Japp-Klingemann reaction; 1 h;
参考文献
Ma, Zhen; Maharramov, Abel M.; Aliyev, Ismayil A.; Aliyeva, Irada N.; Kopylovich, Maximilian N.; Amanullayeva, Gunel I.; Mahmudov, Kamran T.; Pombeiro, Armando J.L.
Journal of Molecular Structure, 2012 , vol. 1019, p. 16 - 20
反应条件
sodium hydroxide in water
T=100°C; 25 h;
参考文献
Schroeder, Sybrin P.; Taylor, Nicholas J.; Jackson, Paula; Franckevicius, Vilius
Organic Letters, 2013 , vol. 15, # 14 p. 3778 - 3781
参考文献
Toivonen; Osara; Ollila
Suomen Kemistilehti B, 1933 , vol. 6, p. 68
Chem. Zentralbl., 1934 , vol. 105, # I p. 212
反应条件
potassium hydroxide; sodium iodide
参考文献
Voitila <Fjaeder>
Annales Academiae Scientiarum Fennicae, Series A, 1937 , vol. 49, # 1 p. 70,79
参考文献
Spencer,T.A. et al.
Journal of Organic Chemistry, 1968 , vol. 33, # 9 p. 3369 - 3373
反应条件
sodium hydride
1.) DMF, -10 deg C; 2.) DMF, 15 min r.t., then 50 deg C, 0.5 h; 3.) DMF, -10 deg C, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Khan, Agha Zul-Quarnain; Sandstroem, Jan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2085 - 2090
参考文献
Desai
Journal of the Chemical Society, 1943 , p. 1079,1081
反应条件
in acetic acid
Cyclization; 30 h; Heating;
参考文献
Suarez, Margarita; Ochoa, Estael; Verdecia, Yamila; Pita,Beatriz; Moran, Lourdes; et al.
Tetrahedron, 1999 , vol. 55, # 3 p. 875 - 884
反应条件
fibrous nano silica sulfuric acid in neat (no solvent)
T=80°C; 0.0166667 h; Green chemistry;
参考文献
Siddiqui, Zeba N.; Khan, Kulsum; Ahmed, Nayeem
Catalysis Letters, 2014 , vol. 144, # 4 p. 623 - 632
反应条件
T=70°C; Condensation; 1 h;
参考文献
Kaupp, Gerd; Schmeyers, Jens; Boy, Juergen
Advanced Synthesis and Catalysis, 2000 , vol. 342, # 3 p. 269 - 280
