5,5-二甲基-1,3-环己二酮合成路线 (共 504 条)
反应条件
1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 7.5 h / 0 - 20 °C
2: RuCl2(tricyclohexylphosphine)2(benzylidene) / benzene / 24 h / 120 °C / Sealed tube; Inert atmosphere
View Scheme
参考文献
Koduri, Naga Durgarao; Scott, Halee; Hileman, Bethany; Cox, Justin D.; Coffin, Michael; Glicksberg, Lindsay; Hussaini, Syed R.
Organic Letters, 2012 , vol. 14, # 2 p. 440 - 443
参考文献
Sokovishina,I.F.; Perekalin,V.V.
Journal of Organic Chemistry USSR (English Translation), 1978 , vol. 14, p. 1688 - 1691
Zhurnal Organicheskoi Khimii, 1978 , vol. 14, # 9 p. 1817 - 1820
反应条件
caesium carbonate in acetonitrile
T=100°C;
参考文献
Liu, Lei; Hu, Jie; Wang, Xiang-Chuan; Zhong, Mei-Jin; Liu, Xue-Yuan; Yang, Shang-Dong; Liang, Yong-Min
Tetrahedron, 2012 , vol. 68, # 27-28 p. 5391 - 5395
反应条件
copper(l) iodide; potassium carbonate in N,N-dimethyl-formamide
T=90°C; 20 h;
参考文献
Fan, Xuesen; He, Yan; Cui, Liangyan; Guo, Shenghai; Wang, Jianji; Zhang, Xinying
European Journal of Organic Chemistry, 2012 , # 4 p. 673 - 677
反应条件
ethanol; sodium ethanolate; copper diacetate
参考文献
Adams et al.
Journal of the American Chemical Society, 1940 , vol. 62, p. 2197,2199
参考文献
Adams et al.
Journal of the American Chemical Society, 1940 , vol. 62, p. 2197,2199
参考文献
Balasubramanian,K. et al.
Synthesis, 1974 , p. 51 - 53
反应条件
1: dimedone With 1,1,1,3,3,3-hexamethyl-disilazane in dichloromethane
4 h;
2: With lithium diisopropyl amide in tetrahydrofuran; hexane; dichloromethane
T=-78°C; 0.75 h;
3: chloro-trimethyl-silane in tetrahydrofuran; hexane; dichloromethane
T=-78 - 20°C; 1 h;
参考文献
Quintiliano, Samir A.P.; Silva Jr., Luiz F.
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3808 - 3810
反应条件
triethylamine in diethyl ether
参考文献
Quintiliano, Samir A.P.; Silva Jr., Luiz F.
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3808 - 3810
参考文献
Iyer; Chakravarti
Journal of the Indian Institute of Science, 1934 , vol. <A> 17, p. 41,47