反应条件
1: AgNO3, N-chlorosuccinimide (NCS), 2,6-lutidine / acetonitrile; H2O / 0.17 h / Ambient temperature
2: NaBH4 / H2O / 2.5 h
3: 83 percent / pyridine / 0 °C
4: KOH / tetrahydrofuran / 1 h / 10 °C
5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT,5 h
6: 65 percent / Na2HPO4, 6percent sodium amalgam / methanol / 2.5 h / 25 °C
View Scheme
参考文献
Ohwa, Masaki; Kogure, Tetsuo; Eliel, Ernest L.
Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2599 - 2601
