2-氨基吡唑并[1,5-a]嘧啶-3-羧酸乙酯合成路线 （共 3 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=100°C; 14 h;
参考文献
GENENTECH, INC.; GIBBONS, Paul; HANAN, Emily; LIU, Wendy; LYSSIKATOS, Joseph P.; MAGNUSON, Steven R.; MENDONCA, Rohan; PASTOR, Richard; RAWSON, Thomas E.; SIU, Michael; ZAK, Mark E.; ZHOU, Aihe; ZHU, Bing-Yan
Patent: WO2011/3065 A2, 2011 ;
Location in patent: Page/Page column 110-111 ;
WO 2011/003065 A2
反应条件
1: triethylamine / ethanol / 0 - 20 °C 2: hydrazine / N,N-dimethyl-formamide / 1 h / 100 °C 3: triethylamine / N,N-dimethyl-formamide / 14 h / 100 °C View Scheme
参考文献
GENENTECH, INC.; GIBBONS, Paul; HANAN, Emily; LIU, Wendy; LYSSIKATOS, Joseph P.; MAGNUSON, Steven R.; MENDONCA, Rohan; PASTOR, Richard; RAWSON, Thomas E.; SIU, Michael; ZAK, Mark E.; ZHOU, Aihe; ZHU, Bing-Yan
Patent: WO2011/3065 A2, 2011 ;
WO 2011/003065 A2
反应条件
1: hydrazine / N,N-dimethyl-formamide / 1 h / 100 °C 2: triethylamine / N,N-dimethyl-formamide / 14 h / 100 °C View Scheme
参考文献
GENENTECH, INC.; GIBBONS, Paul; HANAN, Emily; LIU, Wendy; LYSSIKATOS, Joseph P.; MAGNUSON, Steven R.; MENDONCA, Rohan; PASTOR, Richard; RAWSON, Thomas E.; SIU, Michael; ZAK, Mark E.; ZHOU, Aihe; ZHU, Bing-Yan
Patent: WO2011/3065 A2, 2011 ;
WO 2011/003065 A2
