1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.33 h / -78 - 0 °C / Inert atmosphere 2.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 3.2: 0.67 h / -78 - -60 °C / Inert atmosphere 4.1: hydrogenchloride; water / methanol / 2 h / 20 °C 5.1: potassium hydroxide / ethanol; water / 12 h / Reflux 6.1: pyridine / 20 °C 7.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 8.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 9.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.33 h / -78 - 0 °C / Inert atmosphere 2.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 3.2: 0.67 h / -78 - -60 °C / Inert atmosphere 4.1: hydrogenchloride; water / methanol / 2 h / 20 °C 5.1: potassium hydroxide / ethanol; water / 12 h / Reflux 6.1: pyridine / 20 °C 7.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 8.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 9.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: N-bromosuccinmide / N,N-dimethyl-formamide / 12 h / 0 - 20 &deg;C<br />2: 1H-imidazole / dichloromethane / 1 h / 20 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;